Gene
unc13a
- ID
- ZDB-GENE-140722-1
- Name
- unc-13 homolog A (C. elegans)
- Symbol
- unc13a Nomenclature History
- Previous Names
-
- si:dkey-110c1.7
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calmodulin binding activity and syntaxin-1 binding activity. Predicted to be involved in glutamatergic synaptic transmission and regulated exocytosis. Predicted to act upstream of or within chemical synaptic transmission and exocytosis. Predicted to be active in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sánchez et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR010439 | MUN domain |
| Domain | IPR014770 | Munc13 homology 1 |
| Domain | IPR014772 | Mammalian uncoordinated homology 13, domain 2 |
| Domain | IPR037302 | Protein Unc-13, C2B domain |
| Family | IPR027080 | Protein Unc-13 |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | C2 domain | C2 domain superfamily | Mammalian uncoordinated homology 13, domain 2 | Munc13 homology 1 | MUN domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein Unc-13 | Protein Unc-13, C2B domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AXQ9
|
1784 | |||||||||
|
UniProtKB:A0A8M3AUR4
|
1763 | |||||||||
|
UniProtKB:A0A8M3AUQ9
|
1806 | |||||||||
|
UniProtKB:Q1LXS6
|
1742 | |||||||||
|
UniProtKB:A0A8M3AN14
|
1818 | |||||||||
|
UniProtKB:A0A8M3B5J4
|
1797 | |||||||||
|
UniProtKB:A0A8M3AMA8
|
1799 | |||||||||
|
UniProtKB:A0A8M3AXQ5
|
1816 | |||||||||
|
UniProtKB:A0A8M3AN19
|
1787 | |||||||||
|
UniProtKB:A0A8M9PRV9
|
1223 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:dkey-110c1.7-202
(1)
|
Ensembl | 1,584 nt | ||
| mRNA |
si:dkey-110c1.7-203
(1)
|
Ensembl | 3,832 nt | ||
| mRNA |
unc13a-201
(1)
|
Ensembl | 5,229 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance