Gene

trpc3

ID

ZDB-GENE-140129-1

Name

transient receptor potential cation channel, subfamily C, member 3

Symbol

trpc3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia type 41. Is expressed in nervous system. Orthologous to human TRPC3 (transient receptor potential cation channel subfamily C member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from von Niederhäusern et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpc3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia type 41	Alliance	?Spinocerebellar ataxia 41	616410

Associated With trpc3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR013555	Transient receptor ion channel domain
Family	IPR002153	Transient receptor potential channel, canonical
Family	IPR005459	Transient receptor potential channel, canonical 3
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat