Gene
trip6
- ID
- ZDB-GENE-140106-91
- Name
- thyroid hormone receptor interactor 6
- Symbol
- trip6 Nomenclature History
- Previous Names
-
- zmp:0000001131 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of non-canonical NF-kappaB signal transduction and signal transduction. Part of RNA polymerase II transcription regulator complex. Orthologous to human TRIP6 (thyroid hormone receptor interactor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Raices et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17712 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20901 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20902 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40864 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf2016 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-trip6 | Raices et al., 2017 | |
| MO1-trip6 | N/A | Raices et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001781 | Zinc finger, LIM-type |
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Domain Details Per Protein
| Protein | Length | Zinc finger, LIM-type |
|---|---|---|
|
UniProtKB:A0A8M9PYY5
|
572 | |
|
UniProtKB:A0A8M6YZD4
|
571 | |
|
UniProtKB:A0A8M2BJI7
|
572 | |
|
UniProtKB:A0A2R8PVS7
|
571 | |
|
UniProtKB:A0A1D5NSS7
|
571 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-170H8 | ZFIN Curated Data | |
| Encodes | EST | fc23c06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021471880 (1) | 3706 nt | ||
| Genomic | GenBank:BX322601 (1) | 210153 nt | ||
| Polypeptide | UniProtKB:A0A8M2BJI7 (1) | 572 aa |
- Comparative Orthology
- Alliance
- Raices, M., Bukata, L., Sakuma, S., Borlido, J., Hernandez, L.S., Hart, D.O., D'Angelo, M.A. (2017) Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex. Developmental Cell. 41:540-554.e7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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