Gene
nfat5b
- ID
- ZDB-GENE-140106-7
- Name
- nuclear factor of activated T cells 5b
- Symbol
- nfat5b Nomenclature History
- Previous Names
-
- zmp:0000001047 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in cytoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human NFAT5 (nuclear factor of activated T cells 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nfat5b | Charlton-Perkins et al., 2019 | |
| CRISPR2-nfat5b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR015646 | Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Family | IPR008366 | Nuclear factor of activated T cells (NFAT) |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain | Nuclear factor of activated T cells (NFAT) | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IIR4 | InterPro | 1257 | |||||||||
| UniProtKB:A0A8M9Q2Y6 | InterPro | 1261 | |||||||||
| UniProtKB:A0A8M9QI62 | InterPro | 1188 | |||||||||
| UniProtKB:A0A8M9Q932 | InterPro | 1261 | |||||||||
| UniProtKB:A0A8M3BBF4 | InterPro | 1258 | |||||||||
| UniProtKB:A0A8M9PQA8 | InterPro | 1262 | |||||||||
| UniProtKB:A0AB32TTR5 | InterPro | 1298 | |||||||||
| UniProtKB:A0AB32TU54 | InterPro | 1303 | |||||||||
| UniProtKB:A0AB32TVG3 | InterPro | 1257 | |||||||||
| UniProtKB:A0AB32TZP3 | InterPro | 1229 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nfat5b-201
(1)
|
Ensembl | 1,694 nt | ||
| mRNA |
nfat5b-202
(1)
|
Ensembl | 3,774 nt | ||
| mRNA |
nfat5b-203
(1)
|
Ensembl | 3,180 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-159P16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068222776 (1) | 9891 nt | ||
| Genomic | GenBank:CU929361 (2) | 83836 nt | ||
| Polypeptide | UniProtKB:A0AB32TU54 (1) | 1303 aa |
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Komoike, Y., Matsuoka, M. (2018) In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Journal of hazardous materials. 365:430-439
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