ZFIN is now using GRCz12tu for Genomic Data
Gene
msh5
- ID
- ZDB-GENE-131127-632
- Name
- mutS homolog 5
- Symbol
- msh5 Nomenclature History
- Previous Names
-
- si:ch73-156o22.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable double-stranded DNA binding activity. Predicted to be involved in chiasma assembly. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure 74. Orthologous to human MSH5 (mutS homolog 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 13 | Alliance | ?Premature ovarian failure 13 | 617442 |
| spermatogenic failure 74 | Alliance | Spermatogenic failure 74 | 619937 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Family | IPR011184 | DNA mismatch repair Msh2-type |
| Family | IPR045076 | DNA mismatch repair MutS |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA mismatch repair Msh2-type | DNA mismatch repair MutS | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B4N7 | InterPro | 814 |
Interactions and Pathways
No data available
Plasmids
No data available