Gene
msh5
- ID
- ZDB-GENE-131127-632
- Name
- mutS homolog 5
- Symbol
- msh5 Nomenclature History
- Previous Names
-
- si:ch73-156o22.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded DNA binding activity. Predicted to be involved in chiasma assembly. Predicted to act upstream of or within mismatch repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure. Orthologous to human MSH5 (mutS homolog 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 13 | Alliance | ?Premature ovarian failure 13 | 617442 |
| spermatogenic failure 74 | Alliance | Spermatogenic failure 74 | 619937 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Family | IPR011184 | DNA mismatch repair Msh2-type |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair Msh2-type | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B4N7
|
814 |
Interactions and Pathways
No data available
Plasmids
No data available