Gene

pld5

ID

ZDB-GENE-130530-709

Name

phospholipase D family member 5

Symbol

pld5 Nomenclature History

Previous Names

si:ch211-194e18.2
zmp:0000000706 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable catalytic activity. Orthologous to human PLD5 (phospholipase D family member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa15055	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20617	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa20618	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa26671	Allele with one point mutation	Unknown	Splice Site	ENU
sa33797	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With pld5 Human Ortholog

No data available

Associated With pld5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001736	Phospholipase D/Transphosphatidylase
Domain	IPR032803	PLD-like domain
Family	IPR050874	Diverse function phospholipase D-related protein

Domain Details Per Protein

Protein	Additional Resources	Length	Diverse function phospholipase D-related protein	Phospholipase D/Transphosphatidylase	PLD-like domain
UniProtKB:A0A8M1RIN8	InterPro	481
UniProtKB:A0AB32TLP8	InterPro	525

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 6

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch211-194e18.2-201 (1) Ensembl	Ensembl	2,279 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-194e18.2-202 (1) Ensembl	Ensembl	1,482 nt	Select Tool ZFIN BLAST
mRNA	si:ch211-194e18.2-203 (1) Ensembl	Ensembl	1,521 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-194E18	AL772382	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_003198750 (1)	5604 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005290 (1)	186793 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0AB32TLP8 (1)	525 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	PLD5	1	Ensembl:ENSG00000180287 Gene:200150 HGNC:26879	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Pld5	1	Ensembl:ENSMUSG00000055214 Gene:319455 MGI:2442056	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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