ZFIN is now using GRCz12tu for Genomic Data
Gene
prf1.9
- ID
- ZDB-GENE-131127-344
- Name
- perforin 1.9
- Symbol
- prf1.9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable wide pore channel activity. Predicted to be involved in T cell mediated cytotoxicity; defense response to virus; and immunological synapse formation. Predicted to act upstream of or within immune response; killing of cells of another organism; and leukocyte mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in membrane. Is expressed in gill and kidney. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Varela et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR037300 | Perforin-1, C2 domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Family | IPR052784 | Perforin-1 pore-forming |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B0Z2 | InterPro | 306 | |||||||
| UniProtKB:E7F996 | InterPro | 588 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prf1.9-201
(1)
|
Ensembl | 1,807 nt | ||
| mRNA |
prf1.9-202
(1)
|
Ensembl | 3,672 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance