ZFIN ID: ZDB-GENE-131125-34
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Gene Name: potassium voltage-gated channel, subfamily H (eag-related), member 4a
Gene Symbol: kcnh4a    Nomenclature History

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Previous Name: si:ch211-210g13.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to localize to the integral component of plasma membrane. Is expressed in forebrain and hypothalamus. Orthologous to human KCNH4 (potassium voltage-gated channel subfamily H member 4).
Genome Resources: Alliance (1),  Gene:100148126 (1),  Ensembl(GRCz11):ENSDARG00000062565 (1)
GENE EXPRESSION
All Expression Data: 4 figures from Yelin-Bekerman et al., 2015
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
biu8 Small Deletion Exon 5 Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-kcnh4a 1
PHENOTYPE
Data: 2 figures from Yelin-Bekerman et al., 2015
Observed in:
DISEASE ASSOCIATED WITH kcnh4a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH kcnh4a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ion transport (more)
Cellular Component integral component of membrane (more)
Molecular Function ion channel activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000700 PAS-associated, C-terminal
Repeat IPR001610 PAC motif
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Family IPR003950 Potassium channel, voltage-dependent, ELK
Domain IPR005821 Ion transport domain
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Homologous_superfamily IPR035965 PAS domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA kcnh4a-201 (1)    Ensembl 6680
Select Tool
Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kcnh4a No data available
MARKER RELATIONSHIPS
kcnh4a Contained in: [BAC] CH211-210G13 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001322433 (1)
Select Tool
Genomic GenBank:BX005093 (1) 155392 bp
Select Tool
Polypeptide UniProtKB:A0A142J9E8 (1) 1151 aa
Select Tool
Sequence Information (all 9)
ORTHOLOGY for kcnh4a ( Chr: 3 )
CITATIONS (12)