Gene
msh4
- ID
- ZDB-GENE-131121-643
- Name
- mutS homolog 4
- Symbol
- msh4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded DNA binding activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within mismatch repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 2. Orthologous to human MSH4 (mutS homolog 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dai et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000432 | DNA mismatch repair protein MutS, C-terminal |
| Domain | IPR007696 | DNA mismatch repair protein MutS, core |
| Domain | IPR007860 | DNA mismatch repair protein MutS, connector domain |
| Domain | IPR007861 | DNA mismatch repair protein MutS, clamp |
| Family | IPR011184 | DNA mismatch repair Msh2-type |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036187 | DNA mismatch repair protein MutS, core domain superfamily |
| Homologous_superfamily | IPR036678 | MutS, connector domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA mismatch repair Msh2-type | DNA mismatch repair protein MutS, clamp | DNA mismatch repair protein MutS, connector domain | DNA mismatch repair protein MutS, core | DNA mismatch repair protein MutS, core domain superfamily | DNA mismatch repair protein MutS, C-terminal | MutS, connector domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AK30
|
800 |
Interactions and Pathways
No data available
Plasmids
No data available