Gene
isca2
- ID
- ZDB-GENE-131121-486
- Name
- iron-sulfur cluster assembly 2
- Symbol
- isca2 Nomenclature History
- Previous Names
-
- si:dkey-1f12.2
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple mitochondrial dysfunctions syndrome 4 | Alliance | Multiple mitochondrial dysfunctions syndrome 4 | 616370 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | FeS cluster biogenesis | FeS cluster insertion, C-terminal, conserved site | FeS cluster insertion protein | HesB-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P3Z0
|
155 |
Interactions and Pathways
No data available
Plasmids
No data available