Gene
hs1bp3
- ID
- ZDB-GENE-131121-391
- Name
- HCLS1 binding protein 3
- Symbol
- hs1bp3 Nomenclature History
- Previous Names
-
- si:ch1073-80i24.2
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of autophagy. Orthologous to human HS1BP3 (HCLS1 binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | HCLS1-binding protein 3 | HCLS1-binding protein 3, PX domain | Phox homology | PX domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:F6PCK0 | InterPro | 349 | ||||
UniProtKB:Q6DHB3 | InterPro | 365 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
hs1bp3-201
(1)
|
Ensembl | 1,589 nt | ||
ncRNA |
hs1bp3-002
(1)
|
Ensembl | 687 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-80I24 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001256221 (1) | |||
Genomic | GenBank:CU499333 (1) | 34751 nt | ||
Polypeptide | UniProtKB:Q6DHB3 (1) | 365 aa |
- Holland, P., Knævelsrud, H., Søreng, K., Mathai, B.J., Lystad, A.H., Pankiv, S., Bjørndal, G.T., Schultz, S.W., Lobert, V.H., Chan, R.B., Zhou, B., Liestøl, K., Carlsson, S.R., Melia, T.J., Di Paolo, G., Simonsen, A. (2016) HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nature communications. 7:13889
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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