Gene
pdgfbb
- ID
- ZDB-GENE-131121-332
- Name
- platelet-derived growth factor beta polypeptide b
- Symbol
- pdgfbb Nomenclature History
- Previous Names
-
- sb:eu2436
- si:dkey-110g7.5
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including angiogenesis; platelet-derived growth factor receptor signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within positive regulation of cell division. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu2436 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| Meningioma, SIS-related | 607174 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9PEQ6 | InterPro | 483 | |||
| UniProtKB:A0A2R8Q0D8 | InterPro | 483 | |||
| UniProtKB:A0A8M9PWR6 | InterPro | 482 | |||
| UniProtKB:A0A8M9PRI9 | InterPro | 482 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfbb-201
(1)
|
Ensembl | 3,821 nt | ||
| mRNA |
pdgfbb-202
(1)
|
Ensembl | 4,898 nt | ||
| mRNA |
pdgfbb-203
(1)
|
Ensembl | 7,212 nt |
Interactions and Pathways
No data available
Plasmids
No data available