Gene

pdgfbb

ID

ZDB-GENE-131121-332

Name

platelet-derived growth factor beta polypeptide b

Symbol

pdgfbb Nomenclature History

Previous Names

sb:eu2436
si:dkey-110g7.5

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including angiogenesis; platelet-derived growth factor receptor signaling pathway; and positive regulation of intracellular signal transduction. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; forebrain neural keel; forebrain neural rod; and notochord. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu2436 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdgfbb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
basal ganglia calcification	Alliance	Basal ganglia calcification, idiopathic, 5	615483
		Meningioma, SIS-related	607174

Associated With pdgfbb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023581	Platelet-derived growth factor, conserved site
Domain	IPR000072	PDGF/VEGF domain
Homologous_superfamily	IPR029034	Cystine-knot cytokine

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PEQ6	InterPro	483
UniProtKB:A0A2R8Q0D8	InterPro	483
UniProtKB:A0A8M9PWR6	InterPro	482
UniProtKB:A0A8M9PRI9	InterPro	482

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pdgfbb-201 (1) Ensembl	Ensembl	3,821 nt	Select Tool ZFIN BLAST
mRNA	pdgfbb-202 (1) Ensembl	Ensembl	4,898 nt	Select Tool ZFIN BLAST
mRNA	pdgfbb-203 (1) Ensembl	Ensembl	7,212 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations