Gene
pln2
- ID
- ZDB-GENE-131121-121
- Name
- phospholamban 2
- Symbol
- pln2 Nomenclature History
- Previous Names
-
- plnb (1)
- si:ch211-270g19.5
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- null
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3815 | Allele with one deletion | Unknown | Unknown | not specified |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1P | Alliance | Cardiomyopathy, dilated, 1P | 609909 |
| hypertrophic cardiomyopathy 18 | Alliance | Cardiomyopathy, hypertrophic, 18 | 613874 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-270g19.5-201
(1)
|
Ensembl | 2,620 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(myl7:pln2-2A-TagBFP) |
| 1 | Vicente et al., 2022 | ||
| Tg(myl7:pln2_R9C-2A-TagBFP) |
| 1 | Vicente et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-270G19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068214538 (1) | 498 nt | ||
| Genomic | GenBank:BX276081 (1) | 130240 nt | ||
| Polypeptide | RefSeq:XP_068070639 (1) |
- Vicente, M., Salgado-Almario, J., Valiente-Gabioud, A.A., Collins, M.M., Vincent, P., Domingo, B., Llopis, J. (2022) Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish. Journal of Molecular and Cellular Cardiology. 173:127-140
- Kamel, S.M., van Opbergen, C.J.M., Koopman, C.D., Verkerk, A.O., Boukens, B.J.D., de Jonge, B., Onderwater, Y.L., van Alebeek, E., Chocron, S., Polidoro Pontalti, C., Weuring, W.J., Vos, M.A., de Boer, T.P., van Veen, T.A.B., Bakkers, J. (2021) Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Nature communications. 12:7151
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