Gene

wnk4b

ID
ZDB-GENE-131120-119
Name
WNK lysine deficient protein kinase 4b
Symbol
wnk4b Nomenclature History
Previous Names
  • wnk4l (1)
  • si:dkeyp-61g11.1
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; monoatomic ion homeostasis; and regulation of metal ion transport. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa33153Allele with one point mutationUnknownUnknownENU
1 - 1 of 1
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Sequence Targeting Reagents
No data available
Human Disease
Associated With wnk4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pseudohypoaldosteronism, type IIB 614491
1 - 1 of 1
Associated With wnk4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Family IPR050588 With No Lysine (K) Ser/Thr Protein Kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
1 - 5 of 5
Domain Details Per Protein
Protein Additional Resources Length Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase OSR1/WNK, CCT domain With No Lysine (K) Ser/Thr Protein Kinase
UniProtKB:A0A2R8QPF3 InterPro 1550
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA wnk4b-201 (1) Ensembl 4,473 nt
mRNA wnk4b-202 (1) Ensembl 4,835 nt
mRNA wnk4b-203 (1) Ensembl 9,935 nt
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-104G4ZFIN Curated Data
Contained inBACDKEYP-61G11ZFIN Curated Data
1 - 2 of 2
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanWNK417
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseWnk411
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations