Gene

wnk4b

ID

ZDB-GENE-131120-119

Name

WNK lysine deficient protein kinase 4b

Symbol

wnk4b Nomenclature History

Previous Names

wnk4l (1)
si:dkeyp-61g11.1

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction; monoatomic ion homeostasis; and regulation of metal ion transport. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wnk4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pseudohypoaldosteronism, type IIB	614491

Associated With wnk4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Family	IPR050588	With No Lysine (K) Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase OSR1/WNK, CCT domain	With No Lysine (K) Ser/Thr Protein Kinase
UniProtKB:A0A2R8QPF3	InterPro	1550

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wnk4b-201 (1) Ensembl	Ensembl	4,473 nt	Select Tool ZFIN BLAST
mRNA	wnk4b-202 (1) Ensembl	Ensembl	4,835 nt	Select Tool ZFIN BLAST
mRNA	wnk4b-203 (1) Ensembl	Ensembl	9,935 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations