Gene

a2m2a

ID
ZDB-GENE-131118-12
Name
alpha-2-macroglobulin 2, member a
Symbol
a2m2a Nomenclature History
Previous Names
  • si:ch211-212c13.10 (1)
  • zmp:0000001035
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human A2ML1 (alpha-2-macroglobulin like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa14720Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa35870Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With a2m2a Human Ortholog
No data available
Associated With a2m2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
Conserved_site IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
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Domain Details Per Protein
Protein Additional Resources Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-2-macroglobulin/Complement system Alpha-2-macroglobulin, conserved site Alpha-2-macroglobulin, TED domain Alpha-macroglobulin-like, TED domain Alpha-macroglobulin-like, thiol-ester bond-forming region Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Immunoglobulin E-set Immunoglobulin-like fold Macroglobulin domain Macroglobulin domain MG3 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
UniProtKB:A0A8M1QHK3 InterPro 1437
UniProtKB:A0A8M3B150 InterPro 681
UniProtKB:A0A8M9PIL6 InterPro 1228
UniProtKB:A0A8M3AHH2 InterPro 1436
UniProtKB:A0A8M9PCC9 InterPro 1108
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 15
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:ch211-212c13.10-201 (1)
Ensembl
Ensembl 4,320 nt
ZFIN BLAST
mRNA si:ch211-212c13.10-202 (1)
Ensembl
Ensembl 4,600 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-212C13ZFIN Curated Data
Contained inBACDKEY-52D15ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_005157543 (1)5104 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CR626907 (1)206211 nt
MegaBLAST
PolypeptideUniProtKB:A0A8M1QHK3 (1)1437 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
No data available
Citations
TSV
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