ZFIN is now using GRCz12tu for Genomic Data
Gene

a2m2a

ID
ZDB-GENE-131118-12
Name
alpha-2-macroglobulin 2, member a
Symbol
a2m2a Nomenclature History
Previous Names
  • si:ch211-212c13.10 (1)
  • zmp:0000001035
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human A2ML1 (alpha-2-macroglobulin like 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With a2m2a Human Ortholog
No data available
Associated With a2m2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019742 Alpha-2-macroglobulin, conserved site
Conserved_site IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
Domain IPR001599 Alpha-2-macroglobulin
Domain IPR002890 Macroglobulin domain
Domain IPR009048 Alpha-macroglobulin, receptor-binding
Domain IPR011625 Alpha-2-macroglobulin, bait region domain
Domain IPR011626 Alpha-macroglobulin-like, TED domain
Domain IPR041555 Macroglobulin domain MG3
Domain IPR041813 Alpha-2-macroglobulin, TED domain
Family IPR050473 Alpha-2-macroglobulin/Complement system
Homologous_superfamily IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
Domain Details Per Protein
Protein Additional Resources Length Alpha-2-macroglobulin Alpha-2-macroglobulin, bait region domain Alpha-2-macroglobulin/Complement system Alpha-2-macroglobulin, conserved site Alpha-2-macroglobulin, TED domain Alpha-macroglobulin-like, TED domain Alpha-macroglobulin-like, thiol-ester bond-forming region Alpha-macroglobulin, receptor-binding Alpha-macroglobulin, receptor-binding domain superfamily Immunoglobulin E-set Immunoglobulin-like fold Macroglobulin domain Macroglobulin domain MG3 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
UniProtKB:A0A8M1QHK3 InterPro 1437
UniProtKB:A0A8M3B150 InterPro 681
UniProtKB:A0A8M9PIL6 InterPro 1228
UniProtKB:A0A8M3AHH2 InterPro 1436
UniProtKB:A0A8M9PCC9 InterPro 1108
UniProtKB:A0AB32T6X8 InterPro 1287
UniProtKB:A0AC58HCI7 InterPro 1436
UniProtKB:A0AC58HCJ2 InterPro 1287
UniProtKB:A0AC58HCJ3 InterPro 1331
UniProtKB:A0AC58HCJ4 InterPro 1330
UniProtKB:A0AC58HCJ6 InterPro 1330
UniProtKB:A0AC58HCJ7 InterPro 1331
UniProtKB:A0AC58HCK3 InterPro 1228
UniProtKB:A0AC58HCK4 InterPro 1227
UniProtKB:A0AC58HCK5 InterPro 1122
UniProtKB:A0AC58HCK6 InterPro 1108
UniProtKB:A0AC58HCK7 InterPro 1108
UniProtKB:A0AC58HCK9 InterPro 1108
UniProtKB:A0AC58HCL0 InterPro 1108
UniProtKB:A0AC58HCL1 InterPro 1122
UniProtKB:A0AC58HCL2 InterPro 1108
UniProtKB:A0AC58HCL3 InterPro 1228
UniProtKB:A0AC58HCL4 InterPro 1228
UniProtKB:A0AC58HCL7 InterPro 1107
UniProtKB:A0AC58HCL8 InterPro 1107
UniProtKB:A0AC58HCL9 InterPro 1108
UniProtKB:A0AC58HCM0 InterPro 1108
UniProtKB:A0AC58HCM1 InterPro 1107
UniProtKB:A0AC58HCM2 InterPro 1107
UniProtKB:A0AC58HCM3 InterPro 1107
UniProtKB:A0AC58HCM4 InterPro 1107
UniProtKB:A0AC58HCM5 InterPro 1436
UniProtKB:A0AC58HCM6 InterPro 1108
UniProtKB:A0AC58HCM7 InterPro 1107
UniProtKB:A0AC58HCM8 InterPro 1108
UniProtKB:A0AC58HCM9 InterPro 1228
UniProtKB:A0AC58HCN0 InterPro 681
UniProtKB:A0AC58HCN1 InterPro 1331
UniProtKB:A0AC58HCN6 InterPro 681
UniProtKB:A0AC58HCN7 InterPro 681
UniProtKB:A0AC58HCN9 InterPro 681
UniProtKB:A0AC58HCP1 InterPro 1108
UniProtKB:A0AC58HCP3 InterPro 681
UniProtKB:A0AC58HCP4 InterPro 1108
UniProtKB:A0AC58HCP9 InterPro 1108
UniProtKB:A0AC58HCQ4 InterPro 1107
UniProtKB:A0AC58HCQ7 InterPro 1227
UniProtKB:A0AC58HCQ9 InterPro 1107
UniProtKB:A0AC58HCR0 InterPro 1107
UniProtKB:A0AC58HCR6 InterPro 1108
UniProtKB:A0AC58HCS8 InterPro 681
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA si:ch211-212c13.10-201 (1)
Ensembl
Ensembl 4,320 nt
ZFIN BLAST
mRNA si:ch211-212c13.10-202 (1)
Ensembl
Ensembl 4,600 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Citations
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