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ZIRC
ZFIN ID: ZDB-GENE-131024-3
Gene Name: E2F transcription factor 1
Gene Symbol: e2f1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; anatomical structure maturation; and cell maturation. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1).
Genome Resources: Alliance (1),  Gene:101885420 (1),  Ensembl(GRCz11):ENSDARG00000103868 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa44434 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-e2f1 N/A 1
    PHENOTYPE
    Data: Fig. 5 from Zhang et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH e2f1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH e2f1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM e2f1 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005174533 (1)
    Genomic GenBank:CABZ01117590 (1) 10132 bp
    Polypeptide UniProtKB:H9GY24 (1)
    Sequence Clusters UniGene:66817 (1)
    Sequence Information (all 9)
    ORTHOLOGY for e2f1 ( Chr: 23 )
    CITATIONS (19)