Gene

e2f1

ID
ZDB-GENE-131024-3
Name
E2F transcription factor 1
Symbol
e2f1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; DNA-binding transcription factor activity; and protein dimerization activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process; anatomical structure maturation; and cell maturation. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Zhang et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With e2f1 Human Ortholog
No data available
Associated With e2f1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003316 E2F/DP family, winged-helix DNA-binding domain
Domain IPR032198 E2F transcription factor, CC-MB domain
Family IPR015633 E2F Family
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Homologous_superfamily IPR037241 E2F-DP heterodimerization region
Domain Details Per Protein
Protein Length E2F/DP family, winged-helix DNA-binding domain E2F-DP heterodimerization region E2F Family E2F transcription factor, CC-MB domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:H9GY24
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations