Gene

vclb

ID
ZDB-GENE-131017-1
Name
vinculin b
Symbol
vclb Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity and structural molecule activity. Involved in coronary vasculature morphogenesis. Localizes to adherens junction. Is expressed in mesenchyme pectoral fin; pericardial region; and somite border. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from Cheng et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vclb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1W Alliance Cardiomyopathy, dilated, 1W 611407
hypertrophic cardiomyopathy 15 Alliance Cardiomyopathy, hypertrophic, 15 613255
Associated With vclb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000633 Vinculin, conserved site
Family IPR006077 Vinculin/alpha-catenin
Family IPR017997 Vinculin
Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
Domain Details Per Protein
Protein Length Alpha-catenin/vinculin-like superfamily Vinculin Vinculin/alpha-catenin Vinculin, conserved site
UniProtKB:T2FK05 165
UniProtKB:A0A2R9YJG7 987
UniProtKB:T2FJ15 89
UniProtKB:A0A0S2I7K2 1066
UniProtKB:T2FJK9 188
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations