Gene
vclb
- ID
- ZDB-GENE-131017-1
- Name
- vinculin b
- Symbol
- vclb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity and structural molecule activity. Involved in coronary vasculature morphogenesis. Localizes to adherens junction. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Is expressed in mesenchyme pectoral fin; pericardial region; and somite border. Orthologous to human VCL (vinculin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 8 figures from Cheng et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1W | Alliance | Cardiomyopathy, dilated, 1W | 611407 |
| hypertrophic cardiomyopathy 15 | Alliance | Cardiomyopathy, hypertrophic, 15 | 613255 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alpha-catenin/vinculin-like superfamily | Vinculin | Vinculin/alpha-catenin | Vinculin, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:A0A0S2I7K2
|
1066 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids