Gene

sv2a

ID

ZDB-GENE-131001-1

Name

synaptic vesicle glycoprotein 2A

Symbol

sv2a Nomenclature History

Previous Names

si:ch211-271d10.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable transmembrane transporter activity. Acts upstream of or within neuronal action potential propagation and swimming behavior. Predicted to be located in several cellular components, including cell projection; cytoplasmic vesicle; and synapse. Predicted to be active in neuron projection and synaptic vesicle membrane. Used to study epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhang et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Zhang et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sv2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Developmental and epileptic encephalopathy 113	620772

Associated With sv2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	sv2a^lv105/lv105 (AB)	standard conditions	Zhang et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR005829	Sugar transporter, conserved site
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR005828	Major facilitator, sugar transporter-like
Family	IPR011701	Major facilitator superfamily
Family	IPR022308	Synaptic vesicle protein SV2
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Length	Major facilitator, sugar transporter-like	Major facilitator superfamily	Major facilitator superfamily domain	MFS transporter superfamily	Sugar transporter, conserved site	Synaptic vesicle protein SV2
UniProtKB:E7F6Z2 InterPro	733

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sv2a-201 (1) Ensembl	Ensembl		2,202 nt	Select Tool ZFIN BLAST
mRNA	sv2a-202 (1) Ensembl	Ensembl		8,959 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations