Gene

plbd1b

ID

ZDB-GENE-130531-47

Name

phospholipase B domain containing 1b

Symbol

plbd1b Nomenclature History

Previous Names

si:ch73-139e5.2

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable phospholipase activity. Predicted to be involved in phospholipid catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in extracellular region. Orthologous to human PLBD1 (phospholipase B domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa42009	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With plbd1b Human Ortholog

No data available

Associated With plbd1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR007000	Phospholipase B-like
Homologous_superfamily	IPR043040	Phospholipase B-like, domain 1
Homologous_superfamily	IPR043041	Phospholipase B-like, domain 2
Homologous_superfamily	IPR043042	Phospholipase B-like, domain 3

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Domain Details Per Protein

Protein	Additional Resources	Length	Phospholipase B-like	Phospholipase B-like, domain 1	Phospholipase B-like, domain 2	Phospholipase B-like, domain 3
UniProtKB:A0A8M1Q152	InterPro	576
UniProtKB:A0A8M9QJ48	InterPro	576

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 12

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	plbd1-202 (1) Ensembl	Ensembl		1,491 nt	Select Tool ZFIN BLAST
mRNA	si:ch73-139e5.2-201 (1) Ensembl	Ensembl		1,542 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH73-139E5	CU462845	ZFIN Curated Data
Contained in	BAC	CH211-167D24	CR450737	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_001332510 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CR354584 (1)	218091 nt	Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M1Q152 (1)	576 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	PLBD1	12	Ensembl:ENSG00000121316 Gene:79887 HGNC:26215 OMIM:618486	Conserved genome location (synteny) (1) Phylogenetic tree (1) Amino acid sequence comparison (1)
Mouse	Plbd1	6	Ensembl:ENSMUSG00000030214 Gene:66857 MGI:1914107	Phylogenetic tree (1) Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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