Gene
myo1d
- ID
- ZDB-GENE-130531-15
- Name
- myosin 1D
- Symbol
- myo1d Nomenclature History
- Previous Names
-
- si:ch211-94l19.4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Involved in determination of left/right symmetry. Acts upstream of or within Kupffer's vesicle development. Predicted to be located in several cellular components, including dendrite; early endosome; and perikaryon. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in notochord and tail bud. Orthologous to human MYO1D (myosin ID).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nce16b | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| nce16c | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR | |
| pt31a | Allele with one deletion | Unknown | Frameshift | TALEN | |
| pt31b | Allele with one delins | Unknown | Frameshift | TALEN | |
| pt31c | Allele with one delins | Unknown | Frameshift | TALEN | |
| sa24915 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35308 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35309 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38899 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42047 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myo1d | (2) | |
| MO1-myo1d | N/A | Saydmohammed et al., 2018 |
| MO2-myo1d | N/A | Juan et al., 2018 |
| TALEN1-myo1d | Saydmohammed et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Class I myosin, motor domain | Class I myosin tail homology domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F9L8 | InterPro | 1004 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-180N10 | ZFIN Curated Data | |
| Contained in | BAC | CH73-385F14 | ZFIN Curated Data | |
| Contained in | BAC | CH211-94L19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423964 (1) | |||
| Genomic | GenBank:CT033800 (1) | 113782 nt | ||
| Polypeptide | UniProtKB:E7F9L8 (1) | 1004 aa |
- Comparative Orthology
- Alliance
No data available
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Juan, T., Géminard, C., Coutelis, J.B., Cerezo, D., Polès, S., Noselli, S., Fürthauer, M. (2018) Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry. Nature communications. 9:1942
- Saydmohammed, M., Yagi, H., Calderon, M., Clark, M.J., Feinstein, T., Sun, M., Stolz, D.B., Watkins, S.C., Amack, J.D., Lo, C.W., Tsang, M. (2018) Vertebrate myosin 1d regulates left-right organizer morphogenesis and laterality. Nature communications. 9:3381
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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