Gene

dhx30

ID

ZDB-GENE-130530-833

Name

DEAH (Asp-Glu-Ala-His) box helicase 30

Symbol

dhx30 Nomenclature History

Previous Names

zmp:0000000830 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; RNA binding activity; and helicase activity. Orthologous to human DHX30 (DExH-box helicase 30).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Mannucci et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Mannucci et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dhx30 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with variable motor and speech impairment	617804

Associated With dhx30 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR007502	Helicase-associated domain
Domain	IPR011545	DEAD/DEAH box helicase domain
Domain	IPR011709	DEAD-box helicase, OB fold
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR014720	Double-stranded RNA-binding domain
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	DEAD-box helicase, OB fold	DEAD/DEAH box helicase domain	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Double-stranded RNA-binding domain	Helicase-associated domain	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7FCG0 InterPro	1173
UniProtKB:A0A8M2BIG4 InterPro	1167
UniProtKB:A0A8N7TE51 InterPro	1173

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dhx30-201 (1) Ensembl	Ensembl		3,522 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations