Gene

kcnt2a

ID

ZDB-GENE-130530-783

Name

potassium channel, subfamily T, member 2a

Symbol

kcnt2a Nomenclature History

Previous Names

kcnt2 (1)
zmp:0000000780 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to act upstream of or within potassium ion transport. Predicted to be located in membrane. Is expressed in brain; neural tube; otic vesicle; and tegmentum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Silic et al., 2021

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa9113	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16058	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32858	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With kcnt2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 57	Alliance	Developmental and epileptic encephalopathy 57	617771

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Associated With kcnt2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 2

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	kcnt2-201 (1) Ensembl	Ensembl		1,451 nt	Select Tool ZFIN BLAST
mRNA	kcnt2-202 (1) Ensembl	Ensembl		3,356 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:164963

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-245G22	CT573433	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_068213585 (1)	3864 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR376724 (1)	168441 nt	Select Tool MegaBLAST Ensembl
Polypeptide	RefSeq:XP_068069686 (1)		Select Tool ZFIN BLAST NCBI BLAST UCSC BLAT Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	KCNT2	1	Ensembl:ENSG00000162687 Ensembl:ENSG00000291999 Gene:343450 OMIM:610044 HGNC:18866	Conserved genome location (synteny) (1) Amino acid sequence comparison (2) Phylogenetic tree (1)
Mouse	Kcnt2	1	Ensembl:ENSMUSG00000052726 MGI:3036273 Gene:240776	Conserved genome location (synteny) (1) Amino acid sequence comparison (2) Phylogenetic tree (1)

Citations

Include unpublished citations

Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493

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