Gene
rps6ka5
- ID
- ZDB-GENE-130530-693
- Name
- ribosomal protein S6 kinase, polypeptide 5
- Symbol
- rps6ka5 Nomenclature History
- Previous Names
-
- si:dkeyp-104a11.1
- zmp:0000000690 (1)
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in TORC1 signaling and regulation of DNA-templated transcription. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in cranium. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6491 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15790 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23140 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28901 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36478 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36479 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Protein kinase, ATP binding site | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Ribosomal protein S6 kinase II | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7FE05 | InterPro | 802 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rps6ka5-201
(1)
|
Ensembl | 4,743 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-72L18 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-104A11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_688458 (1) | 2745 nt | ||
| Genomic | GenBank:BX569781 (1) | 170138 nt | ||
| Polypeptide | UniProtKB:E7FE05 (1) | 802 aa |
- Comparative Orthology
- Alliance
- Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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