Gene
itgae.2
- ID
- ZDB-GENE-130530-671
- Name
- integrin, alpha E, tandem duplicate 2
- Symbol
- itgae.2 Nomenclature History
- Previous Names
-
- itgae
- si:ch211-24o10.9
- zmp:0000000668 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Orthologous to human ITGAE (integrin subunit alpha E).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Additional Resources | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin domain superfamily | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q4X6 | InterPro | 800 | ||||||||
| UniProtKB:A0A8M1RMI4 | InterPro | 1098 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
itgae.2-201
(1)
|
Ensembl | 3,070 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-24O10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003200028 (1) | 6106 nt | ||
| Genomic | GenBank:BX294000 (1) | 197371 nt | ||
| Polypeptide | UniProtKB:A0A8M1RMI4 (1) | 1098 aa |
- Comparative Orthology
- Alliance
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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