nek10

ID

ZDB-GENE-130530-570

Name

NIMA-related kinase 10

Symbol

nek10 Nomenclature History

Previous Names

si:ch211-231m23.2
zmp:0000000567 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle G2/M phase transition. Predicted to act upstream of or within protein phosphorylation. Is expressed in female organism. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Newman et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nek10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ciliary dyskinesia 44	Alliance	Ciliary dyskinesia, primary, 44	618781

Associated With nek10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050660	NEK Serine/Threonine Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000225	Armadillo