Gene
drd1a
- ID
- ZDB-GENE-130522-1
- Name
- dopamine receptor D1a
- Symbol
- drd1a Nomenclature History
- Previous Names
-
- D1Aa (1)
- si:ch211-277c7.4
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway; adenylate cyclase-activating adrenergic receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain and inner ear. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| nv1205 | Allele with one deletion | Exon 1 | Unknown | CRISPR |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:E7F359 | InterPro | 363 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-277C7 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017359120 (1) | |||
| Genomic | GenBank:AL935195 (1) | 194053 nt | ||
| Polypeptide | UniProtKB:E7F359 (1) | 363 aa |
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Brown-Panton, C.A., Sabour, S., Zoidl, G.S.O., Zoidl, C., Tabatabaei, N., Zoidl, G.R. (2023) Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish. Frontiers in cell and developmental biology. 11:11502731150273
- Moraes, I.B., Paiva, I.M., Moreira-Júnior, R.E., Sartori, B.M., Franco, R.R., Espindola, F.S., Murgas, L.D.S., Brunialti-Godard, A.L. (2023) Ethanol Preference Leads to Alterations in Telomere Length, Mitochondria Copy Number, and Antioxidant Enzyme Activity in Zebrafish Brains. Frontiers in bioscience (Landmark edition). 28:7373
- Zhou, J., Peng, C., Li, Q., Yan, X., Yang, L., Li, M., Cao, X., Xie, X., Chen, D., Rao, C., Huang, S., Peng, F., Pan, X. (2022) Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells. Frontiers in pharmacology. 13:837810
- Paiva, I.M., de Carvalho, L.M., Di Chiaccio, I.M., de Lima Assis, I., Sánchez, E.N., Garcia, M.B., Ferreira, F.N.A., Cayuela, M.L., Murgas, L.D.S., Godard, A.L.B. (2020) Inhibition of Lrrk2 reduces ethanol preference in a model of acute exposure in zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 100:109885
- Paiva, I.M., Sartori, B.M., Castro, T.F.D., Lunkes, L.C., Virote, B.D.C.R., Murgas, L.D.S., de Souza, R.P., Brunialti-Godard, A.L. (2020) Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Pharmacology, biochemistry, and behavior. 192:172909
- Roche, J., Hergalant, S., Depp, A., Ben Ammar, I., Lafont, A.G., Policar, T., Fontaine, P., Milla, S. (2020) First identification of dopamine receptors in pikeperch, Sander lucioperca, during the pre-ovulatory period. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 36:100747
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Lv, D.J., Li, L.X., Chen, J., Wei, S.Z., Wang, F., Hu, H., Xie, A.M., Liu, C.F. (2019) Sleep Deprivation caused a Memory Defects and Emotional Changes in a Rotenone-based Zebrafish Model of Parkinson's Disease. Behavioural brain research. 372:112031
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