Gene

dner

ID

ZDB-GENE-130502-1

Name

delta/notch-like EGF repeat containing

Symbol

dner Nomenclature History

Previous Names

zmp:0000000696

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in glial cell differentiation; negative regulation of glial cell proliferation; and negative regulation of neural precursor cell proliferation. Predicted to localize to integral component of membrane. Is expressed in immature eye; nervous system; neural keel; and proneural cluster. Orthologous to human DNER (delta/notch like EGF repeat containing).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Hsieh et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Hsieh et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dner Human Ortholog

No data available

Associated With dner Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR045769	Delta and Notch-like epidermal growth factor-related receptor, C-terminal
Family	IPR051830	Neurogenic locus notch homolog
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Delta and Notch-like epidermal growth factor-related receptor, C-terminal	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Neurogenic locus notch homolog
UniProtKB:S4TYY2 InterPro	744

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dner-201 (1) Ensembl	Ensembl		2,235 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations