Gene

map4k3a

ID

ZDB-GENE-130329-1

Name

mitogen-activated protein kinase kinase kinase kinase 3a

Symbol

map4k3a Nomenclature History

Previous Names

si:dkey-31d5.2
zmp:0000000914 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase kinase activity. Predicted to be involved in activation of protein kinase activity; intracellular signal transduction; and regulation of mitotic cell cycle. Predicted to localize to cytoplasm. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map4k3a Human Ortholog

No data available

Associated With map4k3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR021160	Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Citron homology (CNH) domain	Mitogen-activated protein (MAP) kinase kinase kinase kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	STE20/SPS1-related Proline-Alanine-rich Kinase
UniProtKB:A0A8M3B704 InterPro	946
UniProtKB:E7F7S9 InterPro	903
UniProtKB:A0A8M3B465 InterPro	925
UniProtKB:A0A8M9QI59 InterPro	921
UniProtKB:A0A8M9Q7S1 InterPro	883
UniProtKB:A0A8M9PVK2 InterPro	900

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	map4k3a-202 (1) Ensembl	Ensembl	585 nt	Select Tool ZFIN BLAST
mRNA	map4k3a-201 (1) Ensembl	Ensembl	4,870 nt	Select Tool ZFIN BLAST
mRNA	map4k3a-203 (1) Ensembl	Ensembl	2,845 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations