ZFIN is now using GRCz12tu for Genomic Data
Gene
mhc1zka
- ID
- ZDB-GENE-130206-5
- Name
- major histocompatibility complex class I ZKA
- Symbol
- mhc1zka Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA-DNA hybrid ribonuclease activity. Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in gill; intestine; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone marrow cancer (multiple); eye disease (multiple); and liver disease (multiple). Orthologous to several human genes including AZGP1 (alpha-2-glycoprotein 1, zinc-binding); HFE (homeostatic iron regulator); and HLA-A (major histocompatibility complex, class I, A).
- Genome Resources
-
- Alliance (1)
- Gene:100536229 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR001039 | MHC class I alpha chain, alpha1 alpha2 domains |
| Domain | IPR003597 | Immunoglobulin C1-set |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR011161 | MHC class I-like antigen recognition-like |
| Family | IPR050208 | Antigen-presenting and immune regulatory MHC class I-related |
| Homologous_superfamily | IPR011162 | MHC classes I/II-like antigen recognition protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR037055 | MHC class I-like antigen recognition-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Antigen-presenting and immune regulatory MHC class I-related | Immunoglobulin C1-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | MHC classes I/II-like antigen recognition protein | MHC class I alpha chain, alpha1 alpha2 domains | MHC class I-like antigen recognition-like | MHC class I-like antigen recognition-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IEH0 | InterPro | 386 | ||||||||||
| UniProtKB:A0A8M6Z4U0 | InterPro | 940 | ||||||||||
| UniProtKB:U6BNE9 | InterPro | 382 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance