Gene

nlrc11

ID

ZDB-GENE-121214-30

Name

NLR family, CARD domain containing 11

Symbol

nlrc11 Nomenclature History

Previous Names

nlrc3l (1)
Gene26712 (1)
Gene26713 (1)
si:ch211-181d7.3

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have ATP binding activity. Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in several diseases, including CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and gestational trophoblastic neoplasm. Orthologous to several human genes including NLRP13 (NLR family pyrin domain containing 13); NLRP14 (NLR family pyrin domain containing 14); and NLRP2 (NLR family pyrin domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Wu et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlrc11 Human Ortholog

No data available

Associated With nlrc11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR029495	NACHT-associated domain
Domain	IPR041075	NOD2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat

Domain Details Per Protein

Protein	Length	Leucine-rich repeat	Leucine-rich repeat domain superfamily	NACHT-associated domain	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NOD2, winged helix domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7FA88 InterPro	966

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:ch211-181d7.3-202 (1) Ensembl	Havana	6436 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations