Gene
mast1a
- ID
- ZDB-GENE-121214-221
- Name
- microtubule associated serine/threonine kinase 1a
- Symbol
- mast1a Nomenclature History
- Previous Names
-
- si:ch211-212h16.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in brain development; cytoskeleton organization; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in female breast cancer and mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations. Orthologous to human MAST1 (microtubule associated serine/threonine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | Alliance | Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations | 618273 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR015022 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain |
| Domain | IPR037711 | Microtubule-associated serine/threonine-protein kinase, catalytic domain |
| Family | IPR050236 | Serine/threonine-protein kinases, AGC |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR023142 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | Microtubule-associated serine/threonine-protein kinase, catalytic domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily | PDZ domain | PDZ superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AKH8
|
1738 | ||||||||||
|
UniProtKB:E7F0L8
|
1717 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mast1a-201
(1)
|
Ensembl | 5,154 nt | ||
| mRNA |
mast1a-202
(1)
|
Ensembl | 5,103 nt | ||
| mRNA |
mast1a-203
(1)
|
Ensembl | 1,842 nt | ||
| mRNA |
mast1a-204
(1)
|
Ensembl | 4,401 nt | ||
| mRNA |
mast1a-205
(1)
|
Ensembl | 5,004 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance