Gene

si:dkey-26g8.5

ID

ZDB-GENE-121214-19

Name

si:dkey-26g8.5

Symbol

si:dkey-26g8.5 Nomenclature History

Previous Names

ctsl (1)

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to localize to extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V).

Genome Resources

Note

This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With si:dkey-26g8.5 Human Ortholog

No data available

Associated With si:dkey-26g8.5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR000169	Cysteine peptidase, cysteine active site
Active_site	IPR025660	Cysteine peptidase, histidine active site
Active_site	IPR025661	Cysteine peptidase, asparagine active site
Domain	IPR000668	Peptidase C1A, papain C-terminal
Domain	IPR013201	Cathepsin propeptide inhibitor domain (I29)
Domain	IPR039417	Papain-like cysteine endopeptidase
Family	IPR013128	Peptidase C1A
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily