Gene
adgrg4a
- ID
- ZDB-GENE-121129-2
- Name
- adhesion G protein-coupled receptor G4a
- Symbol
- adgrg4a Nomenclature History
- Previous Names
-
- gpr112a
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; intestine; and testis. Orthologous to human ADGRG4 (adhesion G protein-coupled receptor G4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | GAIN domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPS motif | Pentraxin-related |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z267 | InterPro | 1140 | |||||||
| UniProtKB:A0A140LGW6 | InterPro | 1201 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrg4a-201
(1)
|
Ensembl | 4,563 nt | ||
| mRNA |
adgrg4a-202
(1)
|
Ensembl | 1,302 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-11E3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021481193 (1) | 4596 nt | ||
| Genomic | GenBank:BX470159 (1) | 210284 nt | ||
| Polypeptide | UniProtKB:A0A140LGW6 (1) | 1201 aa |
- Huang, S., Zhang, H., Chen, W., Su, N., Yuan, C., Zhang, J., Xiang, S., Hu, X. (2023) CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes. 14(5):
- Torregrosa-Carrión, R., Piñeiro-Sabarís, R., Siguero-Álvarez, M., Grego-Bessa, J., Luna-Zurita, L., Fernandes, V.S., MacGrogan, D., Stainier, D.Y.R., de la Pompa, J.L. (2021) Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Science advances. 7:eabj5445
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
- Geng, F.S., Abbas, L., Baxendale, S., Holdsworth, C.J., Swanson, A.G., Slanchev, K., Hammerschmidt, M., Topczewski, J., and Whitfield, T.T. (2013) Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England). 40(21):4362-4374
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