Gene
kcnh1b
- ID
- ZDB-GENE-121128-4
- Name
- potassium voltage-gated channel, subfamily H (eag-related), member 1b
- Symbol
- kcnh1b Nomenclature History
- Previous Names
-
- zmp:0000000565 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables voltage-gated potassium channel activity. Acts upstream of or within hindbrain formation and somitogenesis. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in gill; nervous system; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Stengel et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Stengel et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | PAC motif | PAS-associated, C-terminal | PAS domain | PAS domain superfamily | Potassium channel, voltage-dependent, EAG | Potassium channel, voltage-dependent, EAG/ELK/ERG-like | Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AXZ2 | InterPro | 965 | |||||||||||
| UniProtKB:K4EHU2 | InterPro | 956 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnh1b-201
(1)
|
Ensembl | 2,871 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Jędrychowska, J., Korzh, V. (2019) Kv2.1 voltage-gated potassium channel et al. in developmental perspective. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(12):1180-1194
- Stengel, R., Rivera-Milla, E., Sahoo, N., Ebert, C., Bollig, F., Heinemann, S.H., Schonherr, R., and Englert, C. (2012) Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. The Journal of biological chemistry. 287(42):35565-35575
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