Gene

adamts17

ID
ZDB-GENE-121030-7
Name
ADAM metallopeptidase with thrombospondin type 1 motif, 17
Symbol
adamts17 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Brunet et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ihb834Allele with one deletionExon 13UnknownCRISPR
China Zebrafish Resource Center (CZRC) (order this)
ihb835Allele with one delinsExon 13UnknownCRISPR
China Zebrafish Resource Center (CZRC) (order this)
1 - 2 of 2
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Sequence Targeting Reagents
Human Disease
Associated With adamts17 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Weill-Marchesani syndrome Alliance Weill-Marchesani 4 syndrome, recessive 613195
1 - 1 of 1
Associated With adamts17 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR010294 ADAMTS/ADAMTS-like, Spacer 1
Domain IPR010909 PLAC
1 - 5 of 14 Show all
Domain Details Per Protein
Protein Additional Resources Length ADAM, cysteine-rich domain ADAMTS/ADAMTS-like ADAMTS/ADAMTS-like, cysteine-rich domain 3 ADAMTS/ADAMTS-like, Spacer 1 ADAMTS and ADAMTS-like ADAMTS, cysteine-rich domain 2 A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide PLAC Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily Zinc finger C2H2-type
UniProtKB:A0A8M9QHG7 InterPro 1134
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adamts17-201 (1)
Ensembl
Ensembl 3,150 nt
ZFIN BLAST
mRNA adamts17-202 (1)
Ensembl
Ensembl 3,069 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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