Gene
xrcc2
- ID
- ZDB-GENE-121029-1
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 2
- Symbol
- xrcc2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity; ATP-dependent DNA damage sensor activity; and DNA binding activity. Predicted to act upstream of or within double-strand break repair via homologous recombination. Predicted to be located in nucleus and replication fork. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2).
- Genome Resources
-
- Alliance (1)
- Gene:553395 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group U | Alliance | ?Fanconi anemia, complementation group U | 617247 |
| primary ovarian insufficiency 17 | Alliance | ?Premature ovarian failure 17 | 619146 |
| spermatogenic failure 50 | Alliance | Spermatogenic failure 50 | 619145 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013632 | DNA recombination and repair protein Rad51-like, C-terminal |
| Domain | IPR020588 | DNA recombination and repair protein RecA-like, ATP-binding domain |
| Family | IPR030547 | DNA repair protein XRCC2 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA recombination and repair protein Rad51-like, C-terminal | DNA recombination and repair protein RecA-like, ATP-binding domain | DNA repair protein XRCC2 | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A3Z0 | InterPro | 314 | ||||
| UniProtKB:A0A2R8QRN2 | InterPro | 302 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance