Gene
apcdd1l
- ID
- ZDB-GENE-121022-3
- Name
- adenomatosis polyposis coli down-regulated 1-like
- Symbol
- apcdd1l Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in plasma membrane. Is expressed in several structures, including atrium; brain; corpuscles of Stannius; eye; and post-vent region. Orthologous to human APCDD1L (APC down-regulated 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | APCDD1 domain | Protein APCDD1 |
|---|---|---|---|---|
| UniProtKB:E7F3Y0 | InterPro | 512 | ||
| UniProtKB:A0A8M9Q271 | InterPro | 512 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apcdd1l-201
(1)
|
Ensembl | 3,178 nt | ||
| mRNA |
apcdd1l-202
(1)
|
Ensembl | 3,271 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-27C11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001341376 (1) | 3151 nt | ||
| Genomic | GenBank:BX323459 (1) | 168538 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q271 (1) | 512 aa |
- Klingbeil, K., Nguyen, T., Fahrner, A., Guthmann, C., Wang, H., Schoels, M., Lilienkamp, M., Franz, H., Eckert, P., Walz, G., Yakulov, T.A. (2021) Corpuscles of Stannius development requires FGF signaling. Developmental Biology. 481:160-171
- Vonica, A., Bhat, N., Phan, K., Guo, J., Iancu, L., Weber, J.A., Karger, A., Cain, J.W., Wang, E.C.E., DeStefano, G.M., O'Donnell-Luria, A.H., Christiano, A.M., Riley, B., Butler, S.J., Luria, V. (2020) Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin. Developmental Biology. 464(1):71-87
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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