Gene
arhgap23a
- ID
- ZDB-GENE-121019-1
- Name
- Rho GTPase activating protein 23a
- Symbol
- arhgap23a Nomenclature History
- Previous Names
-
- sb:eu857
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Predicted to act upstream of or within signal transduction. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu857 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2101 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20091 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33260 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45147 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45148 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | PDZ domain | PDZ domain 6 | PDZ superfamily | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating protein domain | Rho GTPase activation protein |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QAI6
|
1765 | |||||||
|
UniProtKB:A0A8M2BBA8
|
1385 | |||||||
|
UniProtKB:A0A8M2BBG7
|
1561 | |||||||
|
UniProtKB:A0A8M3AQT8
|
1780 | |||||||
|
UniProtKB:A0A8M1RNB3
|
1845 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgap23a-201
(1)
|
Ensembl | 8,042 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-14O21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-232P21 | ZFIN Curated Data | |
| Encodes | EST | eu857 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003198148 (1) | 9329 nt | ||
| Genomic | GenBank:BX537342 (1) | 195436 nt | ||
| Polypeptide | UniProtKB:A0A8M1RNB3 (1) | 1845 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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