Gene
p2ry1
- ID
- ZDB-GENE-121004-2
- Name
- purinergic receptor P2Y1
- Symbol
- p2ry1 Nomenclature History
- Previous Names
-
- si:dkey-151j17.5
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; platelet activation; and relaxation of muscle. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human P2RY1 (purinergic receptor P2Y1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-p2ry1 | Keatinge et al., 2021 | |
| CRISPR2-p2ry1 | Keatinge et al., 2021 | |
| CRISPR3-p2ry1 | Keatinge et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | P2Y purinoceptor 1 |
|---|---|---|---|---|---|
| UniProtKB:A0A0N4SUG9 | InterPro | 355 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151J17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001343319 (1) | 4572 nt | ||
| Genomic | GenBank:CU640433 (1) | 135911 nt | ||
| Polypeptide | UniProtKB:A0A0N4SUG9 (1) | 355 aa |
- Zhao, L., Wang, L.F., Wang, Y.C., Liu, A., Xiao, Q.W., Hu, M.C., Sun, M.Z., Hao, H.Y., Gao, Q., Zhao, X., Chen, D.Y. (2024) Deficiency of P2RY11 causes narcolepsy and attenuates the recruitment of neutrophils and macrophages in the inflammatory response in zebrafish. Cell biology and toxicology. 40:3636
- Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Medrano, M.P., Bejarano, C.A., Battista, A.G., Venera, G.D., Bernabeu, R.O., Faillace, M.P. (2017) Injury-induced purinergic signalling molecules upregulate pluripotency gene expression and mitotic activity of progenitor cells in the zebrafish retina. Purinergic signalling. 13(4):443-465
- Wakisaka, N., Miyasaka, N., Koide, T., Masuda, M., Hiraki-Kajiyama, T., Yoshihara, Y. (2017) An Adenosine Receptor for Olfaction in Fish. Current biology : CB. 27(10):1437-1447.e4
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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