Gene
mcm8
- ID
- ZDB-GENE-120927-1
- Name
- minichromosome maintenance 8 homologous recombination repair factor
- Symbol
- mcm8 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA duplex unwinding and DNA replication. Predicted to be located in chromosome. Predicted to be part of MCM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ovarian insufficiency 10 | Alliance | ?Premature ovarian failure 10 | 612885 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | MCM, AAA-lid domain | MCM domain | MCM OB domain | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F643
|
852 | ||||||||
|
UniProtKB:A0A8M9P0B2
|
693 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance