Gene
tnfrsf11a
- ID
- ZDB-GENE-120910-2
- Name
- tumor necrosis factor receptor superfamily, member 11a, NFKB activator
- Symbol
- tnfrsf11a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to be located in membrane. Human ortholog(s) of this gene implicated in bone development disease and bone remodeling disease (multiple). Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive osteopetrosis 7 | Alliance | Osteopetrosis, autosomal recessive 7 | 612301 |
| familial expansile osteolysis | Alliance | Osteolysis, familial expansile | 174810 |
| Paget's disease of bone 2 | Alliance | {Paget disease of bone 2, early-onset} | 602080 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TNFR/NGFR cysteine-rich region | Tumor necrosis factor receptor superfamily member 11A |
|---|---|---|---|---|
| UniProtKB:A0A8M9PE80 | InterPro | 497 | ||
| UniProtKB:A0A8M3AVZ3 | InterPro | 497 | ||
| UniProtKB:E7F027 | InterPro | 574 | ||
| UniProtKB:A0A8M9P635 | InterPro | 506 | ||
| UniProtKB:A0A8M9Q403 | InterPro | 506 |
1 - 5 of 8 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfrsf11a-201
(1)
|
Ensembl | 3,624 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-285F4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-73N8 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162629 (1) | 2063 nt | ||
| Genomic | RefSeq:NW_018395169 (1) | 314956 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q849 (1) | 574 aa |
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Carnovali, M., Banfi, G., Mariotti, M. (2020) Age-dependent modulation of bone metabolism in zebrafish scales as new model of male osteoporosis in lower vertebrates. GeroScience. 43(2):927-940
- Tsata, V., Kroehne, V., Wehner, D., Rost, F., Lange, C., Hoppe, C., Kurth, T., Reinhardt, S., Petzold, A., Dahl, A., Loeffler, M., Reimer, M.M., Brand, M. (2020) Reactive oligodendrocyte progenitor cells (re-)myelinate the regenerating zebrafish spinal cord. Development (Cambridge, England). 147(24):
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Jeradi, S., Hammerschmidt, M. (2016) Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development. Development (Cambridge, England). 143(7):1205-16
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
1 - 7 of 7
Show