Gene
muc5.1
- ID
- ZDB-GENE-120822-1
- Name
- mucin 5.1, oligomeric mucus/gel-forming
- Symbol
- muc5.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable peptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in esophagus; gill lamella; intestine; and pharynx.
- Genome Resources
- Note
-
This gene is orthologous to BOTH human MUC5AC and MUC5B (evidence: amino acid alignment, phylogenetic tree and synteny). The nomenclature has been updated to avoid implying an orthologous relationship to only one of these genes.
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8866 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15547 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24613 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32517 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44236 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001846 | von Willebrand factor, type D domain |
| Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Domain | IPR008037 | Pacifastin domain |
| Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
| Domain | IPR025155 | WxxW domain |
| Family | IPR050780 | Mucin/von Willebrand/Thrombospondin superfamily |
| Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
| Homologous_superfamily | IPR036201 | Pacifastin domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine knot, C-terminal | Mucin/von Willebrand/Thrombospondin superfamily | Pacifastin domain | Pacifastin domain superfamily | Serine protease inhibitor-like superfamily | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWFC domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain | WxxW domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PH65 | InterPro | 5120 | ||||||||||
| UniProtKB:X1WBL9 | InterPro | 5282 | ||||||||||
| UniProtKB:A0A8M9PN30 | InterPro | 4214 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
muc5.1-201
(1)
|
Ensembl | 16,267 nt |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(muc5.1:muc5.1-TagRFP) |
|
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-198O8 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021470622 (1) | 16109 nt | ||
| Genomic | GenBank:CR854881 (2) | 193195 nt | ||
| Polypeptide | UniProtKB:X1WBL9 (1) | 5282 aa |
- Comparative Orthology
- Alliance
No data available
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Edirisinghe, S.L., Nikapitiya, C., Dananjaya, S.H.S., Park, J., Kim, D., Choi, D., De Zoysa, M. (2022) Effect of Polydeoxyribonucleotide (PDRN) Treatment on Corneal Wound Healing in Zebrafish (Danio rerio). International Journal of Molecular Sciences. 23(21):
- Leal, E., Angotzi, A.R., Gregório, S.F., Ortiz-Delgado, J.B., Rotllant, J., Fuentes, J., Tafalla, C., Cerdá-Reverter, J.M. (2022) Role of the melanocortin system in zebrafish skin physiology. Fish & shellfish immunology. 130:591-601
- Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):
- Liyanage, T.D., Dahanayake, P.S., Edirisinghe, S.L., Nikapitiya, C., Heo, G.J., De Zoysa, M., Whang, I. (2020) Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation. Molecules. 25(13):
- Rajapaksha, D.C., Edirisinghe, S.L., Nikapitiya, C., Dananjaya, S., Kwun, H.J., Kim, C.H., Oh, C., Kang, D.H., De Zoysa, M. (2020) Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish. Marine drugs. 18(11):
- Edirisinghe, S.L., Dananjaya, S.H.S., Nikapitiya, C., Liyanage, T.D., Lee, K.A., Oh, C., Kang, D.H., De Zoysa, M. (2019) Novel pectin isolated from Spirulina maxima enhances the disease resistance and immune responses in zebrafish against Edwardsiella piscicida and Aeromonas hydrophila. Fish & shellfish immunology. 94:558-565
- Udayangani, R.M.C., Dananjaya, S.H.S., Nikapitiya, C., Heo, G.J., Lee, J., De Zoysa, M. (2017) Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish & shellfish immunology. 66:173-184
- Lang, T., Klasson, S., Larsson, E., Johansson, M.E., Hansson, G.C., Samuelsson, T. (2016) Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Molecular Biology and Evolution. 33(8):1921-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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