Gene
shroom3
- ID
- ZDB-GENE-120817-1
- Name
- shroom family member 3
- Symbol
- shroom3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Acts upstream of or within podocyte development and posterior lateral line neuromast development. Predicted to be located in cytoplasm and microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in intestine; otic vesicle; posterior lateral line primordium; pronephros; and spinal cord. Used to study chronic kidney disease. Orthologous to human SHROOM3 (shroom family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chronic kidney disease | WT + MO2-shroom3 + MO4-tp53 | standard conditions | Prokop et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apx/Shrm Domain 1 | Apx/Shrm Domain 2 | Shroom family |
|---|---|---|---|---|
|
UniProtKB:K7X477
|
1600 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
shroom3-201
(1)
|
Ensembl | 4,695 nt | ||
| mRNA |
shroom3-202
(1)
|
Ensembl | 899 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(hsp70l:shroom3-TagRFP) |
|
| 1 | (2) | |
| Tg2(hsp70l:shroom3-TagRFP) |
|
| 1 | (3) | |
| Tg(14xUAS:dnshroom3,DsRed) |
|
| 1 | (4) | |
| Tg(hsp70l:dnshroom3,mCherry) |
|
| 1 | (3) | |
| Tg(UAS:dnshroom3-mCherry,myl7:EGFP) |
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-33N18 | ||
| Contained in | BAC | CH211-134A4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001278851 (1) | 5887 nt | ||
| Genomic | RefSeq:NW_003336762 (1) | 12499 nt | ||
| Polypeptide | UniProtKB:K7X477 (1) | 1600 aa |
- Kindt, L.M., Coughlin, A.R., Perosino, T.R., Ersfeld, H., Hampton, M., Liang, J.O. (2018) Identification of Transcripts Potentially Involved in Neural Tube Closure Using RNA-sequencing. Genesis (New York, N.Y. : 2000). 56(3):e23096
- Prokop, J.W., Yeo, N.C., Ottmann, C., Chhetri, S.B., Florus, K.L., Ross, E.J., Sosonkina, N., Link, B.A., Freedman, B.I., Coppola, C.J., McDermott-Roe, C., Leysen, S., Milroy, L.G., Meijer, F.A., Geurts, A.M., Rauscher, F.J., Ramaker, R., Flister, M.J., Jacob, H.J., Mendenhall, E.M., Lazar, J. (2018) Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD. Journal of the American Society of Nephrology : JASN. 29:1525-1535
- Kozlovskaja-Gumbrienė, A., Yi, R., Alexander, R., Aman, A., Jiskra, R., Nagelberg, D., Knaut, H., McClain, M., Piotrowski, T. (2017) Proliferation-independent regulation of organ size by Fgf/Notch signaling. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yeo, N.C., O'Meara, C.C., Bonomo, J.A., Veth, K.N., Tomar, R., Flister, M.J., Drummond, I.A., Bowden, D.W., Freedman, B.I., Lazar, J., Link, B.A., Jacob, H.J. (2015) Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome research. 25(1):57-65
- Durdu, S., Iskar, M., Revenu, C., Schieber, N., Kunze, A., Bork, P., Schwab, Y., Gilmour, D. (2014) Luminal signalling links cell communication to tissue architecture during organogenesis. Nature. 515(7525):120-4
- Clark, B.S., Cui, S., Miesfeld, J.B., Klezovitch, O., Vasioukhin, V., and Link, B.A. (2012) Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Development (Cambridge, England). 139(9):1599-1610
- Ernst, S., Liu, K., Agarwala, S., Moratscheck, N., Avci, M.E., Nogare, D.D., Chitnis, A.B., Ronneberger, O., and Lecaudey, V. (2012) Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish. Development (Cambridge, England). 139(24):4571-4581
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