Gene

iqsec1b

ID

ZDB-GENE-120813-1

Name

IQ motif and Sec7 domain ArfGEF 1b

Symbol

iqsec1b Nomenclature History

Previous Names

si:dkey-57n24.7

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have ARF guanyl-nucleotide exchange factor activity. Involved in angiogenesis and lymphangiogenesis. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities. Is expressed in liver. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Ningappa et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Manavski et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqsec1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual developmental disorder with short stature and behavioral abnormalities	Alliance	Intellectual developmental disorder with short stature and behavioral abnormalities	618687

Associated With iqsec1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000904	Sec7 domain
Domain	IPR033742	IQ motif and SEC7 domain-containing protein, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR023394	Sec7, C-terminal domain superfamily
Homologous_superfamily	IPR035999	Sec7 domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif and SEC7 domain-containing protein, PH domain	PH-like domain superfamily	Sec7, C-terminal domain superfamily	Sec7 domain	Sec7 domain superfamily
UniProtKB:A0A8M9PVJ2 InterPro	1015
UniProtKB:X1WBR0 InterPro	1134
UniProtKB:A0A8M3BDQ3 InterPro	1216
UniProtKB:A0A8M2BGL9 InterPro	1128
UniProtKB:A0A8M3B6X9 InterPro	1055
UniProtKB:A0A8M2BGL8 InterPro	1121
UniProtKB:A0A8M3AXM6 InterPro	1116
UniProtKB:E7EZE5 InterPro	1252

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	iqsec1b-201 (1) Ensembl	Ensembl		7,336 nt	Select Tool
mRNA	iqsec1b-202 (1) Ensembl	Ensembl		3,405 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations