Gene
iqsec1b
- ID
- ZDB-GENE-120813-1
- Name
- IQ motif and Sec7 domain ArfGEF 1b
- Symbol
- iqsec1b Nomenclature History
- Previous Names
-
- si:dkey-57n24.7
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Acts upstream of or within angiogenesis and lymphangiogenesis. Predicted to be located in cytoplasm. Is expressed in liver. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ningappa et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Manavski et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
intellectual developmental disorder with short stature and behavioral abnormalities | Alliance | Intellectual developmental disorder with short stature and behavioral abnormalities | 618687 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000904 | Sec7 domain |
Domain | IPR033742 | IQ motif and SEC7 domain-containing protein, PH domain |
Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
Protein | Length | IQ motif and SEC7 domain-containing protein, PH domain | PH-like domain superfamily | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:A0A8M9PVJ2
|
1015 | |||||
UniProtKB:X1WBR0
|
1134 | |||||
UniProtKB:A0A8M3BDQ3
|
1216 | |||||
UniProtKB:A0A8M2BGL9
|
1128 | |||||
UniProtKB:A0A8M3B6X9
|
1055 | |||||
UniProtKB:A0A8M2BGL8
|
1121 | |||||
UniProtKB:A0A8M3AXM6
|
1116 | |||||
UniProtKB:E7EZE5
|
1252 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
iqsec1b-201
(1)
|
Ensembl | 7,336 nt | ||
mRNA |
iqsec1b-202
(1)
|
Ensembl | 3,405 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance