Gene
bicd2
- ID
- ZDB-GENE-120717-1
- Name
- bicaudal D homolog 2 (Drosophila)
- Symbol
- bicd2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have dynactin binding activity and dynein complex binding activity. Predicted to be involved in microtubule anchoring at microtubule organizing center and regulation of microtubule cytoskeleton organization. Predicted to localize to Golgi apparatus and cytosol. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominance 2A and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human BICD2 (BICD cargo adaptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Luo et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Luo et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinal muscular atrophy with lower extremity predominant 2A | Alliance | Spinal muscular atrophy, lower extremity-predominant, 2A, autosomal dominant | 615290 |
| spinal muscular atrophy with lower extremity predominant 2B | Alliance | Spinal muscular atrophy, lower extremity-predominant, 2B, autosomal dominant | 618291 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR018477 | Bicaudal-D protein |
Domain Details Per Protein
| Protein | Length | Bicaudal-D protein |
|---|---|---|
|
UniProtKB:X1WDT9
|
846 | |
|
UniProtKB:A0A8N7TEB8
|
809 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance