Gene

dnhd1

ID

ZDB-GENE-120709-97

Name

dynein heavy chain domain 1

Symbol

dnhd1 Nomenclature History

Previous Names

si:dkey-11m19.5

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in flagellated sperm motility. Predicted to be part of inner dynein arm. Predicted to be active in sperm flagellum.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Liu et al., 2022

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Liu et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa5838	Allele with one point mutation	Unknown	Splice Site	ENU
sa13097	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16433	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17550	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa17702	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa21865	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa35044	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa41796	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
CRISPR1-dnhd1		Liu et al., 2022
MO1-dnhd1	N/A	Liu et al., 2022

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Human Disease

Associated With dnhd1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spermatogenic failure 65	Alliance	Spermatogenic failure 65	619712

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Associated With dnhd1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	AB + MO1-dnhd1	standard conditions	Liu et al., 2022

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Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004273	Dynein heavy chain region D6 P-loop domain
Domain	IPR013602	Dynein heavy chain, linker
Domain	IPR024317	Dynein heavy chain, AAA module D4
Domain	IPR024743	Dynein heavy chain, coiled coil stalk
Domain	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region

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Domain Details Per Protein

Protein	Additional Resources	Length	Dynein heavy chain	Dynein heavy chain, AAA1 domain, small subdomain	Dynein heavy chain, AAA 5 extension domain	Dynein heavy chain AAA lid domain	Dynein heavy chain AAA lid domain superfamily	Dynein heavy chain, AAA module D4	Dynein heavy chain, coiled coil stalk	Dynein heavy chain, C-terminal domain	Dynein heavy chain, C-terminal domain, barrel region	Dynein heavy chain, domain 2, N-terminal	Dynein heavy chain, hydrolytic ATP-binding dynein motor region	Dynein heavy chain, linker	Dynein heavy chain, linker, subdomain 3	Dynein heavy chain region D6 P-loop domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9QDX1	InterPro	4503

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 11

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:dkey-11m19.5-202 (1) Ensembl	Ensembl		8,010 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-11M19	BX004876	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021479939 (1)	17339 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX004876 (1)	174893 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9QDX1 (1)	4503 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	DNHD1	11	Ensembl:ENSG00000179532 Gene:144132 HGNC:26532 OMIM:617277	Amino acid sequence comparison (1) Phylogenetic tree (1)
Mouse	Dnhd1	7	Ensembl:ENSMUSG00000030882 Gene:77505 MGI:1924755	Amino acid sequence comparison (1) Phylogenetic tree (1)

Citations

Include unpublished citations

Liu, S., Wei, W., Wang, P., Liu, C., Jiang, X., Li, T., Li, F., Wu, Y., Chen, S., Sun, K., Xu, R. (2022) LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. PLoS Genetics. 18:e1010530e1010530

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