Gene

nlrp1

ID

ZDB-GENE-120709-59

Name

NLR family pyrin domain containing 1

Symbol

nlrp1 Nomenclature History

Previous Names

nlrp6(2of5) (1)
si:ch211-66k16.28 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

null

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Li et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlrp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoinflammation with arthritis and dyskeratosis	617388
		Palmoplantar carcinoma, multiple self-healing	615225
		?Respiratory papillomatosis, juvenile recurrent, congenital	618803
		{Vitiligo-associated multiple autoimmune disease susceptibility 1}	606579

Associated With nlrp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001315	CARD domain
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR025307	FIIND domain
Domain	IPR041075	NOD1/2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Family	IPR050637	NLRP family, innate immunity and inflammation regulators
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily

Domain Details Per Protein

Protein	Length	CARD domain	Death-like domain superfamily	FIIND domain	Leucine-rich repeat domain superfamily	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NLRP family, innate immunity and inflammation regulators	NOD1/2, winged helix domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A386CAB9 InterPro	1355
UniProtKB:A0A8M3B7X8 InterPro	1346
UniProtKB:A0A8M9PXG1 InterPro	1381

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:ch211-66k16.28-201 (1) Ensembl	Ensembl		3,934 nt	Select Tool
mRNA	si:ch211-66k16.28-202 (1) Ensembl	Ensembl		231 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations