Gene

fcho1

ID

ZDB-GENE-120613-1

Name

FCH and mu domain containing endocytic adaptor 1

Symbol

fcho1 Nomenclature History

Previous Names

unm_sa2424

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Acts upstream of or within BMP signaling pathway; convergent extension involved in axis elongation; and dorsal/ventral pattern formation. Located in plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Umasankar et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Umasankar et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fcho1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 76	619164

Associated With fcho1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001060	FCH domain
Domain	IPR018808	Muniscin, C-terminal
Domain	IPR028565	Mu homology domain
Domain	IPR031160	F-BAR domain
Domain	IPR042735	FCHO1, F-BAR domain
Domain	IPR054713	GMIP/FCHO2-like, FCH domain
Homologous_superfamily	IPR027267	AH/BAR domain superfamily