Gene
cyth3a
- ID
- ZDB-GENE-120612-1
- Name
- cytohesin 3a
- Symbol
- cyth3a Nomenclature History
- Previous Names
-
- cyth3
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within epiboly involved in gastrulation with mouth forming second. Is expressed in blastoderm. Orthologous to human CYTH3 (cytohesin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from West et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PH-like domain superfamily | Pleckstrin homology domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E7F2Q0 | InterPro | 396 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyth3a-201
(1)
|
Ensembl | 3,275 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-33F9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-231J9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001342001 (1) | 3086 nt | ||
| Genomic | GenBank:CR932017 (1) | 165406 nt | ||
| Polypeptide | UniProtKB:E7F2Q0 (1) | 396 aa |
- Comparative Orthology
- Alliance
- Ding, Y., Lang, D., Yan, J., Bu, H., Li, H., Jiao, K., Yang, J., Ni, H., Morotti, S., Le, T., Clark, K.J., Port, J., Ekker, S.C., Cao, H., Zhang, Y., Wang, J., Grandi, E., Li, Z., Shi, Y., Li, Y., Glukhov, A.V., Xu, X. (2022) A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. eLIFE. 11:
- Desvignes, T., Sydes, J., Montfort, J., Bobe, J., Postlethwait, J.H. (2021) Evolution after whole genome duplication: teleost microRNAs. Molecular Biology and Evolution. 38(8):3308-3331
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Ichino, N., Serres, M.R., Urban, R.M., Urban, M.D., Treichel, A.J., Schaefbauer, K.J., Greif, L.E., Varshney, G.K., Skuster, K.J., McNulty, M.S., Daby, C.L., Wang, Y., Liao, H.K., El-Rass, S., Ding, Y., Liu, W., Anderson, J.L., Wishman, M.D., Sabharwal, A., Schimmenti, L.A., Sivasubbu, S., Balciunas, D., Hammerschmidt, M., Farber, S.A., Wen, X.Y., Xu, X., McGrail, M., Essner, J.J., Burgess, S.M., Clark, K.J., Ekker, S.C. (2020) Building the vertebrate codex using the gene breaking protein trap library. eLIFE. 9:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gerlai, R., Poshusta, T.L., Rampersad, M., Fernandes, Y., Greenwood, T.M., Cousin, M.A., Klee, E.W., Clark, K.J. (2017) Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants. Behavior Genetics. 47(1):125-139
- West, J.J., Zulueta-Coarasa, T., Maier, J.A., Lee, D.M., Bruce, A.E.E., Fernandez-Gonzalez, R., Harris, T.J.C. (2017) An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress. Current biology : CB. 27(15):2260-2270.e5
- Ding, Y., Long, P.A., Bos, J.M., Shih, Y.H., Ma, X., Sundsbak, R.S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M.J., Lin, X., Ekker, S.C., Redfield, M.M., Olson, T.M., Xu, X. (2016) A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene.. JCI insight. 1(14)
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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