Gene
rfwd3
- ID
- ZDB-GENE-120529-1
- Name
- ring finger and WD repeat domain 3
- Symbol
- rfwd3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and ubiquitin-protein transferase activity. Predicted to be involved in interstrand cross-link repair and protein ubiquitination. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group W | Alliance | ?Fanconi anemia, complementation group W | 617784 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Family | IPR037381 | E3 ubiquitin-protein ligase RFWD3 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase RFWD3 | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:X1WE22
|
632 |
Interactions and Pathways
No data available
Plasmids
No data available